"The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline [goid 1843] [evidence ISS]; Any process that stops, prevents or reduces the frequency, rate or extent of protein kinase activity [goid 6469] [evidence ISS]; The directed movement of a protein from the cytoplasm to the nucleus [goid 6606] [evidence ISS]; The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood [goid 7507] [evidence ISS]; Any process by which a protein is transported to, or maintained in, a specific location [goid 8104] [evidence ISS]; Any process that stops, prevents or reduces the rate or extent of cell proliferation [goid 8285] [evidence ISS]; Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the phosphoinositide 3-kinase cascade [goid 14067] [evidence ISS]; Any process that modulates the frequency, rate or extent of endocytosis [goid 30100] [evidence ISS]; Any process that activates or increases the activity of a GTPase [goid 43547] [evidence IEA]; Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle [goid 45786] [evidence IEA]; Any process that modulates the frequency, rate or extent of insulin receptor signaling [goid 46626] [evidence ISS]; The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands [goid 48009] [evidence ISS]; The directed movement of a motile cell or organism, or the directed growth of a cell guided by a higher concentration, in a concentration gradient of a specific chemical [goid 50918] [evidence ISS]; Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction [goid 51056] [evidence IEA]; Any process that stops, prevents or reduces the frequency, rate or extent of the protein kinase B signaling cascade, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B [goid 51898] [evidence ISS]"