"Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond [goid 6467] [pmid 11397793] [evidence TAS]; Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond [goid 6467] [pmid 11297543] [evidence TAS]; The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle [goid 6749] [pmid 11397793] [evidence TAS]; The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism [goid 6810] [evidence IEA]; A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface [goid 6915] [pmid 11297543] [evidence NAS];  [goid 6980] [pmid 11297543] [evidence TAS]; A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus [goid 9266] [pmid 11397793] [evidence NAS]; Any process that modulates the frequency, rate or extent of signal transduction [goid 9966] [pmid 11297543] [evidence NAS]; A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus [goid 10033] [pmid 11397793] [evidence IDA]; A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient [goid 22900] [evidence IEA]; The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate [goid 30154] [pmid 11297543] [evidence NAS]; Any process by which DNA is protected from damage by, for example, oxidative stress [goid 42262] [pmid 11397793] [evidence NAS]; Any process by which DNA is protected from damage by, for example, oxidative stress [goid 42262] [pmid 11297543] [evidence NAS]; A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus [goid 42542] [pmid 11397793] [evidence IDA]; Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA [goid 45449] [pmid 11297543] [evidence NAS]; Any process that maintains the redox environment of a cell or compartment within a cell [goid 45454] [pmid 11397793] [evidence TAS]"