"The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance [goid 1503] [evidence IEA]; The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism [goid 6810] [evidence IEA]; The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes [goid 6895] [pmid 11331584] [evidence IDA]; A type of vesicle-mediated transport in which cells take up external materials or membrane constituents by the invagination of small region of the plasma membrane to form a new membrane-bounded vesicle [goid 6897] [evidence IEA]; The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor [goid 7218] [pmid 9756851] [evidence IDA]; The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult) [goid 7275] [evidence IEA]; The directed movement of substances from endosomes to lysosomes [goid 8333] [pmid 11331584] [evidence IDA]; Any process induced by extracellular signals that directly activates any of the steps required for cell death by apoptosis [goid 8624] [pmid 14985763] [evidence IMP]; Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form [goid 10468] [pmid 18258592] [evidence IMP]; The process whereby a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse [goid 14902] [pmid 18258592] [evidence IMP]; A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a vesicle [goid 16050] [pmid 15992544] [evidence IDA]; The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate [goid 30154] [evidence IEA]; The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment [goid 32509] [pmid 11331584] [evidence IDA]; A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms [goid 32868] [pmid 15992544] [evidence IMP]; Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis [goid 43066] [pmid 14985763] [evidence IDA]; The directed movement of the hexose monosaccharide glucose into a cell or organelle [goid 46323] [pmid 15992544] [evidence IMP]; The series of molecular signals generated as a consequence of the nerve growth factor receptor binding to one of its physiological ligands [goid 48011] [pmid 14985763] [evidence IMP]; Transport of a vesicle from the plasma membrane to the endosome [goid 48227] [pmid 11331584] [evidence IDA]; Any process that stops or reduces the activity of the enzyme lipoprotein lipase [goid 51005] [pmid 10085125] [evidence IDA]"