"Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways [goid 165] [pmid 11877449] [evidence NAS]; A process which directly inhibits any of the steps required for cell death by apoptosis [goid 6916] [pmid 11877449] [evidence NAS]; Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack [goid 6952] [pmid 11877449] [evidence NAS]; Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat [goid 6955] [evidence IEA]; The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand [goid 7169] [pmid 11877449] [evidence NAS]; Any process by which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of cytokines to their cognate receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes [goid 7259] [pmid 11877449] [evidence IEP]; Any process by which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of cytokines to their cognate receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes [goid 7259] [evidence ISS]; Any process that activates or increases the rate or extent of cell proliferation [goid 8284] [evidence ISS]; Any process that activates or increases the rate or extent of cell proliferation [goid 8284] [pmid 11877449] [evidence IDA]; Any series of molecular signals generated as a consequence of a cytokine or chemokine binding to a cell surface receptor [goid 19221] [pmid 11877449] [evidence TAS]; The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte [goid 30224] [evidence ISS]; The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte [goid 30224] [pmid 11877449] [evidence IEP]; The process whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage [goid 30225] [pmid 11877449] [evidence NAS]; Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein [goid 42517] [pmid 11877449] [evidence IEP]; Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein [goid 42517] [evidence ISS]; Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein [goid 42523] [evidence ISS]; Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein [goid 42523] [pmid 11877449] [evidence IEP]; Any biological process involved in the maintenance of an internal equilibrium [goid 42592] [pmid 11877449] [evidence NAS]; Any process that stops, prevents or reduces the frequency, rate or extent of macrophage activation [goid 43031] [pmid 11877449] [evidence NAS]; Any process that activates or increases the frequency, rate or extent of DNA-dependent transcription [goid 45893] [pmid 11877449] [evidence NAS]"