"The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine [goid 1822] [pmid 12552133] [evidence ISS]; The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes [goid 1889] [pmid 12552133] [evidence ISS]; The hydrolysis of a peptide bond or bonds within a protein [goid 6508] [evidence IEA]; The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids [goid 6629] [evidence IEA]; The chemical reactions and pathways involving triacylglycerol, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triacylglycerols are important components of plant oils, animal fats and animal plasma lipoproteins [goid 6641] [evidence IEA]; The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester [goid 6644] [evidence IEA]; The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus [goid 8202] [evidence IEA]; The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues [goid 8203] [evidence IEA]; A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment [goid 9267] [pmid 16407292] [evidence ISS]; Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein [goid 16540] [pmid 14622975] [evidence IDA]; Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein [goid 16540] [pmid 16912035] [evidence TAS]; Generation of cells within the nervous system [goid 22008] [pmid 12552133] [evidence ISS]; The process whereby a relatively unspecialized cell acquires specialized features of a neuron [goid 30182] [pmid 12552133] [evidence ISS]; Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors [goid 32803] [evidence IEA]; A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms [goid 32869] [pmid 12552133] [evidence ISS]; The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids [goid 42157] [evidence IEA]; Any process involved in the maintenance of an internal equilibrium of cholesterol within an organism or cell [goid 42632] [pmid 17170371] [evidence IMP]; Any process that stops or reduces the activity of an enzyme [goid 43086] [evidence IEA]; Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptosis [goid 43525] [pmid 17051583] [evidence IMP]"