"The process that regulates the coordinated growth and sprouting of blood vessels giving rise to the organized vascular system [goid 1569] [evidence IEA]; A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level [goid 1666] [evidence IEA]; The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth [goid 1701] [evidence IEA]; The process by which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor [goid 3100] [pmid 2649896] [evidence IDA]; Any process that modulates the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion [goid 6885] [evidence IEA]; The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand [goid 7205] [evidence IEA]; Any process that mediates the transfer of information from one cell to another [goid 7267] [pmid 12379507] [evidence IDA]; The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood [goid 7507] [evidence IEA]; The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms [goid 7585] [evidence IEA]; The process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure [goid 8217] [evidence IEA]; The regionalization process by which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation [goid 9953] [evidence IEA]; Any process that activates or increases the frequency or rate of heart contraction [goid 10460] [pmid 2649896] [evidence IDA]; Any process that increases the rate, frequency, or extent of the orderly movement of endothelial cells into the extracellular matrix to form an endothelium [goid 10595] [pmid 8999856] [evidence TAS]; The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell [goid 14032] [evidence IEA]; A series of reactions, mediated by the intracellular phosphoinositide 3-kinase (PI3K). PI3K cascades lie downstream of many cell surface receptor linked signaling pathways and regulate numerous cellular functions [goid 14065] [pmid 17078114] [evidence IDA]; A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the artery. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The artery is a vessel carrying blood away from the heart [goid 14824] [pmid 1725334] [evidence TAS]; The directed movement of the hexose monosaccharide glucose into, out of, within or between cells [goid 15758] [evidence IEA]; Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels [goid 19229] [evidence IEA]; A series of molecular signals in which a cell uses calcium ions to convert an extracellular signal into a response [goid 19722] [pmid 1917960] [evidence IDA]; A series of molecular signals in which a cell uses calcium ions to convert an extracellular signal into a response [goid 19722] [pmid 10770212] [evidence IDA]; The regulated release of a peptide hormone from secretory granules [goid 30072] [pmid 10770212] [evidence IDA]; The process of renal water excretion [goid 30146] [evidence IEA]; The process of renal sodium excretion [goid 30147] [evidence IEA]; The directed movement of nitric oxide, nitrogen monoxide, into, out of, within or between cells [goid 30185] [pmid 16820593] [evidence IDA]; Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation [goid 30195] [pmid 16820593] [evidence TAS]; Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) [goid 30818] [evidence IEA]; A G-protein coupled signaling pathway that results in the activation of phospholipase D, causing an increase in cellular levels of phosphatidic acid [goid 31583] [evidence IEA]; Any process resulting in the inhibition or termination of the activity of protein kinase C [goid 42313] [pmid 16820593] [evidence IDA]; The process by which the anatomical structures of middle ear are generated and organized. Morphogenesis pertains to the creation of form. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window) [goid 42474] [evidence IEA]; Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit [goid 43179] [evidence IEA]; Any process that activates or increases the frequency, rate or extent of JUN kinase activity [goid 43507] [pmid 12847114] [evidence IDA]; A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor [goid 45321] [pmid 16820593] [evidence TAS]; Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide [goid 45429] [pmid 8999856] [evidence TAS]; Any process that increases cell size [goid 45793] [pmid 12847114] [evidence IDA]; Any process that activates or increases the frequency, rate or extent of mitosis [goid 45840] [pmid 10770212] [evidence IDA]; Any process that activates or increases the frequency, rate or extent of smooth muscle contraction [goid 45987] [evidence IEA]; Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells [goid 46887] [pmid 10770212] [evidence IDA]; A series of molecular signals in which a cell uses a water-soluble inositol phosphate to convert an extracellular signal into a response [goid 48016] [pmid 1917960] [evidence IDA]; The process by which the anatomical structures of blood vessels are generated and organized. Morphogenesis pertains to the creation of form. The blood vessel is the vasculature carrying blood [goid 48514] [evidence IEA]; Any process that activates or increases the rate or extent of smooth muscle cell proliferation [goid 48661] [pmid 10393673] [evidence IDA]; The process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate [goid 51216] [evidence IEA]; Any process that increases the concentration of calcium ions in the cytosol during the process of G-protein signaling coupled to IP3 second messenger [goid 51482] [evidence IEA]; Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric-oxide synthase [goid 51771] [pmid 16820593] [evidence IDA]"