"The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance [goid 1503] [evidence IEA]; A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface [goid 6915] [pmid 11911826] [evidence IDA]; Any process that stops, prevents or reduces the frequency, rate or extent of bone mineralization [goid 30502] [pmid 16870619] [evidence IDA]; A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a secretory granule in a mast cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion [goid 33364] [evidence ISS]; A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion [goid 33371] [evidence ISS]; A process by which a protease is maintained in a secretory granule in a mast cell and prevented from moving elsewhere [goid 33373] [evidence ISS]; A process by which the protease granyme B is maintained in a secretory granule in a T cell and prevented from moving elsewhere [goid 33382] [evidence ISS]; Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of cytokines from a cell or group of cells [goid 50710] [evidence ISS]; The hydrolysis of a peptide bond or bonds within a protein during protein maturation, the process leading to the attainment of the full functional capacity of a protein [goid 51605] [evidence ISS]"