"The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, the mesodermal cell that gives rise to bone [goid 1649] [evidence ISS]; The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is the excretory organ of the fetus which develops into the kidney and is formed from the rear portion of the nephrogenic cord [goid 1656] [evidence ISS]; A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level [goid 1666] [evidence ISS]; The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes [goid 1889] [evidence ISS]; Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation [goid 1937] [pmid 17404841] [evidence IMP]; Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix [goid 1952] [evidence ISS]; The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell [goid 7165] [evidence IEA]; A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state [goid 7265] [evidence ISS]; Any process that stops, prevents or reduces the frequency, rate or extent of the proliferation of neuroblasts [goid 7406] [evidence ISS]; The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.) [goid 7420] [evidence ISS]; The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands [goid 7422] [evidence ISS]; The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood [goid 7507] [evidence ISS]; Any process in an organism in which a change in behavior of an individual in response to repeated exposure to a visual cue [goid 8542] [evidence ISS]; A series of reactions, mediated by the intracellular phosphoinositide 3-kinase (PI3K). PI3K cascades lie downstream of many cell surface receptor linked signaling pathways and regulate numerous cellular functions [goid 14065] [evidence ISS]; The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues [goid 21510] [evidence ISS]; The process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function [goid 21897] [evidence ISS]; The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon [goid 21987] [evidence ISS]; The process whereby neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier [goid 22011] [evidence ISS]; A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins [goid 30036] [evidence ISS]; Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix [goid 30199] [evidence ISS]; The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells [goid 30325] [evidence ISS]; Any process that stops, prevents or reduces the frequency, rate or extent of cell migration [goid 30336] [pmid 16648142] [evidence IMP]; Any process that activates or increases the activity of a GTPase of the Ras superfamily [goid 32320] [evidence ISS]; The series of events that restore integrity to a damaged tissue, following an injury [goid 42060] [evidence ISS]; Any process that stops, prevents or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus [goid 42992] [evidence ISS]; Any process that stops, prevents or reduces the frequency, rate or extent of MAP kinase activity [goid 43407] [evidence ISS]; Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade [goid 43409] [evidence ISS]; The deposition or aggregation of coloring matter in an organism, tissue or cell [goid 43473] [evidence ISS]; Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptosis [goid 43525] [evidence ISS]; Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels [goid 43535] [pmid 17404841] [evidence IMP]; Any process that modulates the frequency, rate or extent of bone tissue loss (resorption) [goid 45124] [evidence ISS]; Any process that modulates the frequency, rate or extent of glia cell differentiation [goid 45685] [evidence ISS]; Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity [goid 45762] [evidence ISS]; Any process that modulates the frequency, rate or extent of angiogenesis [goid 45765] [pmid 17404841] [evidence IMP]; Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle [goid 45786] [evidence IEA]; The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter [goid 48485] [evidence ISS]; The process by which the anatomical structures of the eye are generated and organized. Morphogenesis pertains to the creation of form. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field [goid 48593] [evidence ISS]; Any process that stops, prevents or reduces the frequency, rate or extent of oligodendrocyte differentiation [goid 48715] [evidence ISS]; The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure [goid 48745] [evidence ISS]; The process by which the anatomical structures of arterial blood vessels are generated and organized. Morphogenesis pertains to the creation of form. Arteries are blood vessels that transport blood from the heart to the body and its organs [goid 48844] [evidence ISS]; The process by which the anatomical structures of the forebrain are generated and organized. Morphogenesis pertains to the creation of form. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions) [goid 48853] [evidence ISS]; The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory [goid 50890] [pmid 17299016] [evidence IMP]; Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction [goid 51056] [evidence IEA]"