"The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA [goid 6260] [pmid 11909973] [evidence TAS]; The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication [goid 6268] [pmid 11909973] [evidence TAS]; The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway [goid 6281] [pmid 11909973] [evidence TAS]; The ligation by DNA ligase of DNA strands. Ligation occurs after polymerase action to fill the gap left by the action of endonucleases during base-excision repair [goid 6288] [pmid 9600082] [evidence IDA]; Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin [goid 6325] [pmid 15504738] [evidence NAS]; Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin [goid 6325] [pmid 11909973] [evidence NAS]; The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA [goid 6334] [pmid 11909973] [evidence NAS]; Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter [goid 6357] [pmid 7797075] [evidence IDA]; A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response [goid 48015] [pmid 15504738] [evidence NAS]"