"The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton) [goid 1501] [evidence IEA]; The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, the mesodermal cell that gives rise to bone [goid 1649] [evidence IEA]; The process whereby a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage [goid 2062] [evidence IEA]; Any process that modulates the frequency, rate or extent of DNA-dependent transcription [goid 6355] [evidence IEA]; Any process that activates or increases the rate or extent of cell proliferation [goid 8284] [evidence IEA]; Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity [goid 40036] [evidence IEA]; Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates [goid 42487] [evidence IEA]; Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling [goid 45879] [evidence IEA]; Any process that activates or increases the frequency, rate or extent of transcription from the RNA polymerase II promoter [goid 45944] [evidence IEA]; A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state [goid 48469] [evidence IEA]; The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton) [goid 1501] [evidence IEA]; The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, the mesodermal cell that gives rise to bone [goid 1649] [pmid 12217689] [evidence TAS]; The process whereby a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage [goid 2062] [evidence IEA]; Any process that modulates the frequency, rate or extent of DNA-dependent transcription [goid 6355] [evidence IEA]; Any process that activates or increases the rate or extent of cell proliferation [goid 8284] [evidence IEA]; Any process that stops, prevents or reduces the frequency, rate or extent of transcription [goid 16481] [pmid 11965546] [evidence IDA]; Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity [goid 40036] [evidence IEA]; Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates [goid 42487] [evidence IEA]; Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling [goid 45879] [evidence IEA]; Any process that activates or increases the frequency, rate or extent of transcription from the RNA polymerase II promoter [goid 45944] [evidence IEA]; A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state [goid 48469] [evidence IEA]"