"The hydrolysis of a peptide bond or bonds within a protein [goid 6508] [evidence IEA]; Any process that modulates the occurrence or rate of cell death by apoptosis [goid 42981] [evidence IEA]; Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels [goid 1525] [evidence IEA]; The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system [goid 1841] [evidence IEA]; The hydrolysis of a peptide bond or bonds within a protein [goid 6508] [pmid 12888622] [evidence IDA]; A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface [goid 6915] [evidence IEA]; The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood [goid 7507] [evidence IEA]; Any process induced by extracellular signals that directly activates any of the steps required for cell death by apoptosis [goid 8624] [pmid 11048727] [evidence EXP]; The conversion of proteins that induce or sustain apoptosis to an active form [goid 8633] [pmid 14644197] [evidence EXP]; The process whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage [goid 30225] [evidence IEA]; Any process that modulates the occurrence or rate of cell death by apoptosis [goid 42981] [evidence IEA]; Any process that activates or increases the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade [goid 43123] [pmid 12761501] [evidence IEP]"