"A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level [goid 1666] [pmid 99104162] [evidence IDA]; Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter [goid 6357] [pmid 9434189] [evidence TAS]; A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation) [goid 6950] [evidence IEA]; Any process that stops, prevents or reduces the frequency, rate or extent of transcription during mitosis [goid 7068] [pmid 9887100] [evidence IDA]; The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry [goid 7368] [evidence ISS]; The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood [goid 7507] [pmid 16287139] [evidence IMP]; The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood [goid 7507] [evidence ISS]; Any process that stops, prevents or reduces the frequency, rate or extent of transcription [goid 16481] [pmid 99104162] [evidence IMP]; Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity [goid 30511] [evidence ISS]; Any process that activates or increases the rate or extent of progression through the cell cycle [goid 45787] [evidence ISS]; Any process that activates or increases the frequency, rate or extent of DNA-dependent transcription [goid 45893] [evidence ISS]"